How Long Does HRT Take to Work? The Timeline the Trials Actually Measured
Hot flashes separate from placebo by week 4 in the estradiol patch trials, and oral HRT cut their frequency 75% versus placebo in the Cochrane pooled data. Vaginal symptoms take 12 weeks. Weight and hair carry no timeline at all: the label lists them only as side effects. The week-by-week timeline, with every claim traced to a drug label or a randomized trial.